Matthias Selbach studied biology at the University of Muenster (Germany). For his PhD thesis he moved to the Max Planck Institute of Infection Biology in Berlin where he investigated signaling events elicited by bacterial pathogens in mammalian cells. In 2004 he went on to the lab of Matthias Mann in Odense (Denmark) and followed him to the Max Planck Institute of Biochemistry (Munich).
Being a postdoctoral fellow in a renowned proteomics lab, quantitative mass spectrometry rapidly became a cornerstone of his work. For example, he used proteomics to study the in vivo metabolism of Salmonella during infection. He also developed the first screening method for endogenous protein-protein interactions by quantitative proteomics. Since 2007 Matthias heads the independent junior research group “Cell signaling and mass spectrometry” at the Max Delbruck Center for Molecular Medicine in Berlin. Since 2010 he is also associate professor at the Berlin Medical School (Charité).
Major research interests of his lab are cellular signal transduction networks, regulation of gene expression, protein-protein interaction and in vivo quantitative proteomics. The lab developed pulsed SILAC (pSILAC) as the first method to measure changes in cellular protein production on a global scale. Recently, the Selbach lab used parallel metabolic pulse labeling of mRNAs and proteins for global quantification of mammalian gene expression control.
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